DGD Awards


Editor-in-Chief Prize(Most cited)
Nagata, R. and Igaki, T.
Cell competition: Emerging mechanisms to eliminate neighbors.
DGD 60 (9), 522–530, 2018

Total citation: 11
Wiley Prize (Most downloaded)
Sakano, H.
Developmental regulation of olfactory circuit formation in mice.
DGD 62 (4) 199–213, 2020

Total download:1495
Young Investigator Paper Award (DGD 奨励賞)
Original Articles:
Inamori, S., Fujii, M., Satake, S., Iida, H., Teramoto, M., Sumi, T., Meno, C., Ishii, Y. and Kondoh, H.
Modeling early stages of endoderm development in epiblast stem cell aggregates with supply of extracellular matrices.
DGD 62 (4), 243–259, 2020

Inamori & Fujii et al. established a novel cell culture protocol that recapitulates the process of gastrulation from an epiblast stem cell line of mouse. Although cell culture protocols to reproduce the endoderm differentiation have been reported, what makes the authors’ protocol unique is that it is intended to establish a culture system depending on more cell autonomy than other systems. The authors first established the pluripotent epiblast stem cell line from Foxa2-2A-EGFP knockin mouse embryos. The cells, when cultured as a non-adherent aggregate in the ordinary pluripotent cell maintenance medium, expressed EGFP in a few days of culture. The authors regarded this as equivalent state around the onset of endoderm differentiation. Considering that the gastrulating cells in vivo migrate over the laminin rich basement membrane, the authors embedded the aggregate in Matrigel. In a few days, groups of cells were found, migrating from the central core to peripheral mantle in the aggregate. This is reminiscent of the cell movement in the node-proximal gastrulation. The authors examined the cells in culture for various marker gene expression specific to steps of endodermal/cardiac mesodermal differentiation by RT-PCR and immunostaining. They clearly showed that the cell aggregate recapitulates the gastrulation-dependent endoderm precursor development, deriving three distinct cell populations, the definitive endoderm, the cardiac mesodermal precursor and the gastrulation-ready epiblast. The protocol established by the authors provides a very useful system that models gastrulation in mouse. The paper by Inamori & Fujii et al. is an excellent piece of work, fully deserving of Young Investigator Prize.

Das, P., Salazar, J. L., Li-Kroeger, D., Yamamoto, S., Nakamura, M., Sasamura, T., Inaki, M., Masuda, W., Kitagawa, M., Yamakawa, T., and Matsuno, K.
Maternal almondex, a neurogenic gene, is required for proper subcellular Notch distribution in early Drosophila embryogenesis.
DGD 62 (1), 80–93, 2020

The Drosophila almondex gene (amx) has been known as a gene encoding a positive regulator of Notch signaling since the 1980s. There has been, however, some confusion about how it works and what is the role during development, because one of the two amx mutants used in the past was a frameshift mutant, while the other mutant contained a deletion of a gene other than amx and a duplication of another gene. Das et al. created a new CDS deletion mutant, using CRISPR techniques, and reexamined the function of amx. Using the mutant and its derivatives, the authors showed that amx is a neurogenic gene that acts as a maternal but not zygotic gene, and that its deletion causes female sterility. Additionally, they found that amx is partially involved in ectoderm/mesodermal fate separation. Thus, the authors have cleared up the confusion over the years. In addition, they found that the loss of amx lead to the abnormal subcellular distribution of Notch protein transiently in the early development, but despite the authors' various experimental efforts, definite explanation for their observation was not obtained. However, the authors' work provides a solid starting point for future detailed studies of the mechanism of Notch signaling activation by the amx gene, and also a useful starting point for studies of TM2D3, the human gene homologue of amx, which has been implicated in Alzheimer's disease. The paper by Das et al. is fully deserving of the Young Investigator Prize.

Review Articles:
Enny, A., Flaherty, K., Mori, S., Turner, N. and Nakamura, T.
Developmental constraints on fin diversity.
DGD 62 (5), 311–325, 2020
Onimaru, K.
The evolutionary origin of developmental enhancers in vertebrates: Insights from non-model species.
DGD 62 (5), 326–333, 2020


Editor-in-Chief Prize(Most cited)
Sasaki, Hiroshi
Roles and regulations of Hippo signaling during preimplantation mouse development.
DGD 59 (1) 12-20, 2017

Total citation: 13
Wiley Prize (Most downloaded)
Kono, Nobuaki; Arakawa, Kazuharu
Nanopore sequencing: Review of potential applications in functional genomics.
DGD 61 (5) 316-326, 2019

Total download:8171
Young Investigator Paper Award (DGD 奨励賞)
Shiori Yamamoto, Yuji Uchida, Tomomi Ohtani, Erina Nozaki, Chunyang Yin, Yoshihiro Gotoh, Nayuta Yakushiji-Kaminatsui, Tetsuya Higashiyama, Takamasa Suzuki. Tatsuya Takemoto, Yo-ichi Shiraishi and Atsushi Kuroiwa
Hoxa13 regulates expression of common Hox target genes involved in cartilage development to coordinate the expansion of the autopodal anlage
DGD 61 (3) 228-251, 2019

In this study, the authors identified Hoxa13 target genes involved in the regulation of autopod development. They compared ChIP-seq data of HOXA11 (zeugopod-specific) and HOXA13 (autopod-specific), and determined autopod-specific enhancer sequences regulating Bmp2 and Tshz2, which were confirmed by knockout of these sequences. They also identified genes whose expression levels changed in Hoxa13/Hoxd11-13 double knockout embryos; among these genes, those proximal to the HOXA13 binding sites were determined as candidate Hoxa13 target genes. The authors analyzed the alterations in the expression of these genes in the knockout embryos in great detail, in the spatio-temporal order and in the context of cartilage development. The authors successfully provided an overview of how Hoxa13 gene regulates autopod cartilage development. This is an excellent study, fully deserving of a DGD young investigator’s award.

Misaki Shirahama, Ichie Steinfeld,Akari Karaiwa, Shigeru Taketani, Astrid Vogel‐Höpker, Paul G. Layer, Masasuke Araki.
Change in the developmental fate of the chick optic vesicle from the neural retina to the telencephalon.
DGD 61 (3) 252-262, 2019

Previous studies have indicated that optic vesicle (OV) consists of regions with different developmental plasticity, and their fates are influenced by surrounding tissues. In this study, the authors further examined influences of surrounding tissues for developmental fates of chick OV in detail by using transplantation and organ culture techniques, and found that OV can differentiate to telencephalon under the influence of forebrain tissue.
The authors first showed that transplanted OV free from surrounding surface ectoderm and mesenchyme in the original position of recipient embryos showed down regulation of neural retina-specific genes, Rax and Vsx2. Meanwhile, characteristics of telencephalon including the expression of specific marker genes such as Emx1 were increased in the proximal region of the transplant adjacent to recipient forebrain, and retinal pigmented epithelium markers Mitf and Otx2 were upregulated in the distal region of the explant underneath epidermis. The authors then carried out explant culture of OV, and found that OV alone with or without the surrounding tissues expressed Rax, while OVs without surrounding tissues cultured in close contact with a fragment of the anterior forebrain showed down-regulation of Rax and increased Emx1 expression.
The results together suggest that OV have developmental plasticity not only for retinal tissues but also for brain, and OV can differentiate to telencephalon under the influence of forebrain tissues. The results provide new insight concerning developmental plasticity of OV and its control, and form the reason, I would recommend that this manuscript is suitable for the 2019’s DGD young investigator’s award.

Hirono Kina, Takashi Yoshitani, Kazuko Hanyu-Nakamura, Akira Nakamura
Rapid and efficient generation of GFP‐knocked‐in Drosophila by the CRISPR‐Cas9‐mediated genome editing
DGD 61 (4) 265-275, 2019

H. Kina and T. Yoshitani et al. established a novel, rapid and efficient strategy to generate GFP knock-in lines of Drosophila, in which GFP is knocked in the target gene through CRISPR-Cas9 mediated genome editing to produce a fusion protein. The authors presented several knock-in lines of posterior group genes as well as some other genes. The authors demonstrated, employing beautiful pictures, that the expression of GFP in each line recapitulates the original gene expression pattern in most cases. They properly discussed not only advantages of the strategy but also possible negative effects of GFP-fusion of the target gene on its function. The knock-in strains have been deposited in the Kyoto Stock Center for researchers. The authors described the strategy clearly, characterized the generated strains exactly and provided the community of developmental biologists with useful resources. This is an excellent study, worth receiving a Young Investigator Paper Award 2019.


Editor-in-Chief Prize(Most cited)
Wiley Prize (Most downloaded)
Masaki Kinoshita, Austin Smith
Pluripotency Deconstructed.
Dev Growth Differ, 60-1: 44-52, 2018

Total download:1519
Young Investigator Paper Award (DGD 奨励賞)
Takebayashi-Suzuki, Kimiko, Konishi, H., Miyamoto, T., Nagata, T., Uchida, M., Suzuki, A
Coordinated regulation of the dorsal-ventral and anterior-posterior patterning of Xenopus embryos by the BTB/POZ zinc finger protein Zbtb14. 
Dev Growth Differ,60-3:158-173

A number of previous studies have indicated that BMP and WNT signalings play crucial roles on establishment of dorsal-ventral (DV) and anterior-posterior (AP) axes, respectively, during embryogenesis. In this study, the author clarified the functions of Zbtb14 encoding zinc-finger and BTB domain-containing protein in axis formation in Xenopus embryos. The author found that Zbtb14 enhanced posterior neural development while it repressed anterior neural development as well as ventral epidermal differentiation by loss-of-functions and gain-of-function experiments in Xenopus embryos. The author also examined mechanisms of the Zbtb14 functions by biochemical experiments by using cultured cells. As a result, she revealed that Smad1/8 which transmit BMP signal to induce ventral development, were decreased by Ztbt14. In addition, Zbtb14 interacted with I-Smads and Smurf1/2 which repress and degrade Smad1/8 via ubiquitination, respectively. With regard to the Wnt signal which enhances posterior neural development, the authors found that Ztbt14 stabilized b-catenin transmitting Wnt signal and interacted with b-TrCP which degrades b-catenin via ubiquitination. The results together suggest that Zbtb14 enhances dorsal neural development and represses anterior neural development and ventral epidermal differentiation via controlling stability of the BMP and Wnt singling molecules. This manuscript reports novel molecular mechanisms of axis formation in Xenopus embryos by Zbtb14 which was selected as a BMP-regulated gene by the author, and therefore is suitable for the DGD Award of this year.

Tatsuya Kamimura, Toshiyuki Yamagishi, Yuji Nakajima
Avian coronary endothelium is a mosaic of sinus venosus- and ventricle-derived endothelial cells in a region-specific manner
Dev Growth Differ. 60-2, 97-111

Coronary endothelium is the source of blood vessels supporting the life-long activity of myocardium. In avian, coronary endothelium has been known to be derived from proepicardial organ (PEO) that transiently appears during heart development. PEO consists of surface mesothelium and internal mesenchyme, but their developmental fate has not been fully understood. In this work, the authors used methods to separately label mesothelium and mesenchyme with fluorescent reagents or GFP gene marker. Taking advantage of the quail-chick chimera technique, the authors provided new information on the cell lineage relationship in PEO and contributed to the research toward establishing a unified view of vertebrate hear development.

Kazutaka Hosoda, Minako Motoishi, Takuya Kunimoto, Osamu Nishimura, Byulnim Hwang, Sumire Kobayashi, Shigenobu Yazawa, Makoto Mochii, Kiyokazu Agata, Yoshihiko Umesono
Role of MEKK1 in the anterior-posterior patterning during planarian regeneration.
Dev Growth Differ 60-6, 341-353

Previous studies using planarians indicated that the counteraction of anterior ERK activity and posterior b-catenin-dependent signaling determines the head to tail polarity of the body, after physiological binary fission or body amputation leading to the full body regeneration. However, this mechanism did not account for the highly stable proportion of regenerated body subdivisions, i.e., head, prepharyngeal, pharyngeal, and tail. The authors discovered a Mekk1 (Mitogen-activated protein kinase kinase kinase 1) gene in planarian genome (Djmekk1), for the first time in non-vertebrates, and demonstrated that Djmekk1 activity determines the prepharyngeal subdivision, which is indicated as Djndk2-positive and Djndk-negative region. When Djmekk1 was knocked down, the prepharyngeal subdivision was specifically lost, causing more anterior positioning of the pharynx compared to the normal. The authors further analyzed possible cross-talks of Djmekk1 activity with other signaling systems, and concluded that Djmekk1 activates anterior ERK signaling and inhibits posterior b-catenin-dependent signaling, suggesting that these interactions are involved in the determination and positioning of prepharyngeal subdivision. This study provides a new insight into the problem how the complete planarian body plan is re-established after regeneration. Moreover, the reported Mekk1 action may widely apply to various other developmental systems.


Editor-in-Chief Prize(Most cited)
Kazumasa Ohashi
Tohoku University
Roles of cofilin in development and its mechanisms of regulation.
Dev Growth Differ. 57 (4) 275-290, 2015

Total citation: 9
Wiley Prize (Most downloaded)
Hiroshi Sasaki
Osaka University
Roles and regulations of Hippo signaling during preimplantation mouse development.
Dev Growth Differ, 59 (1) 12-20, 2017

Total download:1135
Young Investigator Paper Award (DGD 奨励賞)
Hidetaka Katow, Teppei Kanaya, T. Ogawa, R. Egawa and H. Yawo
Regulation of axon arborization pattern in the developing ciliary ganglion: Possible involvement of caspase 3
(DGD 59-3, 115-128)

Caspases are known as the major executor molecules of the process of apoptosis. However, recent studies have suggested their involvement in the neural network formation via regulation of growth cone stability or modulation of axon arborization. In this study, the authors tested this new model focusing on caspase 3. After confirming that a dominant-negative (DN) form of caspase 3 subunit inhibits the enzyme activity via hetero-dimerization with wild type caspase 3 subunit, the authors overexpressed the DN caspase 3 in the midbrain of E2 chicken embryos by electroporation of vector DNA. The electroporated midbrain neurons, labeled by tdTomato expression, served as pre-sysnaptic neurons in the ciliary ganglia (CG). The authors carefully analyzed arborization patterns of midbrain-derived axons in CGs by 3D imaging using two-photon microscopy. The authors found that expression of DN caspase 3 resulted in the reduction in the axon branching and elongation of the terminal branch in CGs during developmental stages E6 to E8. This study clearly marks a step toward elucidation of possibly multi-faceted caspase functions in neural circuit development.

Mayoko Tsuji, M. Morishima, K. Shimizu, S. Morikawa, M. Heglind, S. Enerback, T. Ezaki and J. Tamaoki
Foxc2 influences alveolar epithelial cell differentiationduring lung development
(DGD 59-6, 501-514)

Organogenesis is a complex process involving cell differentiation, cell proliferation and morphogenesis. Precise description of gene activities and their requirement for organogenesis at the cellular level is crucial for understanding the relationship of gene and phenotype. In this paper Tsui and colleagues described genetic requirement of the transcription factor Foxc2 in the mouse lung development. The authors noted that previously uncharacterized lung phenotype of Foxc2 knockout mouse embryos and described cellular change in the mutants. They also showed Foxc expression pattern in the lung of E10.5 embryos reported by LacZ knock in allele of Foxc2. Overall, the concise set of data and descriptions are useful piece of information for developmental biologists and this work should remain as a valuable information in the literature.

Kanami Noguchi, Ryota Ishikawa, M. Kawaguchi, K. Miyoshi, T. Kawasaki, T. Hirata, M. Fukui, S. Kuratani, M. Tanaka and Y. Murakami
Expression patterns of Sema3A in developing amniote limbs: With reference to the diversification of peripheral nerve innervation
(DGD 59-4, 270-285)

It is interesting to know how altered regulations of muscular, skeletal and neuronal development are linked to diversification of limb morphology among amniote species. In this manuscript, the authors compared patterns of the expression of Sema3A, a repulsive molecule of axon, with morphologies of innervating spinal nerves and patterns of cartilage marker expression in developing limbs of four amniote species, chick, turtle, gecko and mouse in detail. The results show that at the timing of innervation, the expression patterns of Sema3A as well as innervation patterns of spinal nerves that avoid Sema3A-expressing regions, are similar among the species. Meanwhile, in later embryonic stages when diversification of limb morphology including cartilage patterns, becomes evident, both Sema3A expression and the innevation also showed diverse patterns corresponding to different morphologies of limbs. In addition, Sema3A expression is partially overlapped with cartilage marker expression. The results together suggest that changes of cartilage development result in altered innervation via differential expression of Sema3A in limbs, which may lead to morphological and functional adaptation for environments. All data are clearly presented, and the authors’ claims and hypothesis are persuasive. Form the reasons, this manuscript provides valuable information to developmental biologists and therefore, is suitable for the DGD award.


Editor-in-Chief Prize(Most cited)
Noriyuki Kishi , Kenya Sato, Erika Sasaki and Hideyuki Okano
Common marmoset as a new model animal for neuroscience research and genome editing technology DGD 56 (1) 53?62, 2014

Total citation: 18
Wiley-Blackwell Prize (Most downloaded)
Luan Wen and Yun-Bo Shi
Regulation of growth rate and developmental timing by Xenopus thyroid hormone receptor α.
DGD 58(1), 106-115, 2016

Total download:2606
Young Investigator Paper Award (DGD 奨励賞)
Junming Chen, Xiuli Lian, Xiuli Lian, Juan Du, Songhua Xu, Jianen Wei, Lili Pang, Chanchan Song, Lin He and Shie Wang
Inhibition of phosphorylated Ser473-Akt from translocating into the nucleus contributes to 2-cell arrest and defective zygotic genome activation in mouse preimplantation embryogenesis
(DGD. 58-3, 280-292)

Zygotic genome activation (ZGA) is important for pre-implantation development. Previous studies indicated that failure of ZGA and 2-cell arrest in mouse embryogenesis was closely associated, and that PI3K signaling played a role on ZGA. In addition, it has been also reported that a phosphorylated Akt (pSer247-Akt), a down-stream signaling molecule of PI3K, is localized in nucleus of 2-cell embryos. However, physiological significance of nuclear localization of pSer247-Akt in ZGA and in pre-implantation embryogenesis beyond 2-cell stage has been unclear.
In this manuscript, the authors demonstrated the effects of the inhibitors of Akt, API-2 and MK2206, in cultured pre-implantation mouse embryos, and found that the inhibitors caused 2-cell arrest as well as suppression of nuclear localization of pSer247-Akt and of the expression of the ZGA marker genes, MuERV-L and eIF-1A. The results clearly demonstrated the importance of nuclear localization of pSer473-Akt in 2-cell embryos for ZGA and development beyond 2-cell stage.
This study newly reveals molecular mechanisms underlying ZGA and pre-implantation embryogenesis. In addition, data and description in this manuscript are clearly presented and support the authors’ claims.

Yukika Saga, Tomoka Inamura, Nao Shimada and Takefumi Kawata
Regulation of ecmF gene expression and genetic hierarchy among STATa, CudA, and MybC on several prestalk A-specific gene expressions in Dictyostelium
(DGD 58-4, 383-399)

Cellular slime molds have served as attractive model organisms in developmental studies owing to their exhibiting clearly distinct cell changes in temporal order, starting from amoeboid cells ending in mature fruiting bodies. This study focused on the stage when slugs develop into the fruiting body and identified STATa, a STAT family transcription factor (TF), as a key player in the regulation of prestalk A cells. Utilizing various TF mutants and reporter genes, the authors show that the gene regulatory network associated with STATa is not a linear cascade form but involves parallel interacting pathways. This study took advantage of the unique feature of the cellular slime molds, and was very carefully performed.

Yudai Tokumasu, Atsuo Iida, Zi Wang, Satoshi Ansai, Masato Kinoshita and Atsuko Sehara-Fujisawa.
ADAM12-deficient zebrafish exhibit retardation in body growth at the juvenile stage without developmental defects
(DGD 58-4, 409-421)

ADAM (a disintegrin and metalloprotease) family metalloproteases are implicated in development and physiology of metazoans. Although mouse ADAM12 has been shown to be involved in brown adipose function and muscle development, full understanding of its function has been difficult due to variability in the phenotypes of adam12 knockout mice. In this study Tokumasu et al., attempted to elucidate adam12 function by mutating the single adam12 homologue in zebrafish. adam12 expression was studied by in situ hybridization and by GFP transgenic reporter. Knock out strain created using CRISPER-CAS9 technology caused shorter body length phenotype, although the homozygous mutants fishes are viable and fertile. This work utilized the genome engineering technologies to elucidate the function of a gene of general interest. With concise text and solid data, this work should become a solid addition to the literature.


Editor-in-Chief Prize(Most cited)
Masamitsu Konno, Atsushi Hamabe, Shinichiro Hasegawa, Hisataka Ogawa, Takahito Fukusumi, Shimpei Nishikawa, Katsuya Ohta, Yoshihiro Kano, Miyuki Ozaki, Yuko Noguchi, Daisuke Sakai, Toshihiro Kudoh, Koichi Kawamoto, Hidetoshi Eguchi, Taroh Satoh, Masahiro Tanemura, Hiroaki Nagano, Yuichiro Doki, Masaki Mori and Hideshi Ishii
Adipose-derived mesenchymal stem cells and regenerative medicine.
DGD (2013) 55 (3), 309-318, 2013

Total citation: 32
Wiley-Blackwell Prize (Most downloaded)
Kwok Yeung Tsang, Danny Chan and Kathryn S. E. Cheah
Fate of growth plate hypertrophic chondrocytes: Death or lineage extension?
DGD 57 (2), 179-192, 2015

Total download: 733
Young Investigator Paper Award (DGD 奨励賞)
Eriko Nishitani, Chong Li, Jaehoon Lee, Hiroyo Hotta, Yuta Katayama, Masahiro Yamaguchi and Tsutomu Kinoshita
Pou5f3.2-induced proliferative state of embryonic cells during gastrulation of Xenopus laevis embryo
DGD 57 (9), 591-600, 2015

Yasuhiko Tosa, Ayako Hirao, Ikumi Matsubara, Masahumi Kawaguchi, Makiko Fukui, Shigeru Kuratani and Yasunori Murakami
Development of the thalamo-dorsal ventricular ridge tract in the Chinese soft-shelled turtle, Pelodiscus sinensis
DGD 57 (1), 40-57. 2015

Caixia Li, Pingping Zhang and Jieruo G.
miR-29a modulates tumor necrosis factor-α-induced osteogenic inhibition by targeting Wnt antagonists.
DGD 57 (3), 264-273 (2015)


Editor-in-Chief Prize(Most cited)
Ramesh S Pillai and Shinichiro Chuma
piRNAs and their involvement in male germline development in mice
DGD (2012) 54 (1) 78-92, 2012

Total citation:39
Wiley-Blackwell Prize (Most downloaded)
Daisuke Mashiko, Samantha A. M. Young, Masanaga Muto, Hirotaka Kato, Kaori Nozawa, Masaki Ogawa, Taichi Noda, Yeon-Joo Kim, Yuhkoh Satouh, Yoshitaka Fujihara and Masahito Ikawa
Feasibility for a large scale mouse mutagenesis by injecting CRISPR/Cas plasmid into zygotes.
DGD 56 (1), 122-129

Total download:3237
Young Investigator Paper Award (DGD 奨励賞)
Maha Anani, Ikuo Nobuhisa, Mitsujiro Osawa, Atsushi Iwama, Kaho Harada, Kiyoka Saito and Tetsuya Taga
Sox17 as a candidate regulator of myeloid restricted differentiation potential
DGD 56 (6), 469-479, 2014

It has been reported that Sox17 is expressed in fetal hematopoietic progenitor cells in the aorta-gonad-mesonephros (AGM) region in embryos while Sox17 is involved in maintenance and differentiation of adult hematopoietic progenitors in bone marrow. Based on the information, this manuscript showed functions of Sox17 in fetal hematopoietic progenitor cells in the AGM by forced expression of Sox17 in those cells. The authors indicated that the Sox17 expressing progenitor cells preferentially developed to common myeloid progenitors (CMPs) after transplantation into irradiated recipient mice. In addition, Sox17-expressing progenitors cells gave rise to CMPs as well as granulocyte/macrophage progenitors (GMPs) in cultures, and their self-renewal proliferation was maintained for some passages. Moreover, those cells showed increased expression of key genes for hematopoietic differentiation compared with that in control cells without Sox17 transduction, and they formed the mixed type colonies consisting of multi-lineage hematopoietic cells in culture. In summary, this manuscript clearly demonstrated critical functions of Sox17 for maintenance and differentiation of fetal hematopoietic progenitors cells, in particular myeloid lineage, by detailed transplantation and culture experiments, and therefore, I would recommend this manuscript for the DGD award.

Akiha Nishihara and Chikara Hashimoto
Tail structure is formed when blastocoel roof contacts blastocoel floor in Xenopus laevis
DGD 56 (3), 214-222

To perform classical “organizer” experiments using amphibian embryos, a popular procedure is the “Einsteck” operation making an opening in the blastocoel roof for transplantation of heterologous tissues. In this paper, the authors demonstrated using Xenopus embryos that blastocoel roof opening causing blastocoel fluid leak and allowing direct contact of blastocoel roof and floor is sufficient for initiating secondary tail development, without transplanting any other tissues. The development of secondary tail is under the same regulation as normal tail, in the Fgf signal dependence and sequential activation of a set of stage-specific genes. These observations indicate that the nature of “tail organizer” and the mechanisms underlying tail development deserve reinvestigation using modern analytical tools. Because of this impact, this paper is deserving of a DGD award.

Yoshiyuki Matsubara, Atsushi Sakai, Atsushi Kuroiwa and Takayuki Suzuki
Efficient embryonic culture method for, and its early developmental stages
DGD 56 (8), 573-582

This paper describes early developmental staging of the Japanese striped snake, Elaphe quadrivirgata. The ex vivo culture method developed by the authors is especially useful to study the progress of somite segmentation and helped the authors to elucidate previously obscure early stage of embryonic development prior to egg deposition. This paper is likely to become a standard reference for reptilian embryology.


Editor-in-Chief Prize(Most cited)
Erina Kuranaga
Caspase signaling in animal development
DGD (2011) 53-2, 137-148

Total citation:11
Wiley-Blackwell Prize (Most downloaded)
Ken-ichi Nishijima and Shinji Iijima
Transgenic chickens
Dev Growth Differ (2013) 55-1, 207-216

Total download:2285
Young Investigator Paper Award (DGD 奨励賞)
Yosuke Horikawa, Haruka Matsumoto, Fumika Yamaguchi, Satomi Ishida and Shigeki Fujiwara.
Transcriptional regulation in the early ectodermal lineage of ascidian embryos.
DGD (2013) 55-9, 776-785.

GATA factors play major roles in the cell lineage segregation and cell type determination. In this study, the authors investigated transcriptional regulation in the early ectodermal lineage in ascidians, starting from animal hemispheres of 16-cell stage embryos. They first determined animal hemisphere-specific enhancers associated with ephrin Ad, Tgf-NA1 and Fz4 genes, and identified a common octamer motif related to GATAAGGG, which included the classical GATA motif. The authors analyzed mutational effects and demonstrated that the octamer motif, rather than singlet GATA motifs, is essential for the activity of the enhancers. The authors confirmed using EMSA that the Ciona GATA factor binds to the octamer motif very strongly in vitro, whereas not all classical GATA motifs bind the same factor. In summary, the authors demonstrated the direct action of the GATA factor in the activation of the epidermal lineage-specific genes through the binding to the octamer motif, providing new insight into the GATA factor-dependent developmental gene regulation.

Shoko Mori, Yuki Moriyama, Kumiko Yoshikawa, Tomoyo Furukawa and Hiroki Kuroda.
β-adrenergic signaling promotes posteriorization in Xenopus early development
DGD (2013) 55-3, 350-358.

This paper shows the function of –βadrenergic signaling (Adrβ2) in Xenopus early development. They first showed that Adrβ2 is expressed in the early phase of Xenopus development. Then examined its function by gain and loss of function of Adrβ2, that is, injection of Adrβ2 and antisense morpholino oligomer for Adrβ2 (Adrβ2-MO) into 2 cell stage embryos, respectively. Loss of function of Adrβ2 resulted in defects of posterior structures of the larvae, while gain of function, injection of mRNA or treatment by Adrenalin, resulted in defects in the anterior structures. The effects of adrenaline was canceled by Adrβ2-MO, and enhanced by Adrβ2 mRNA injection. The results indicated that adrenagic signaling is involved in antero-posterior axis formation by posteriorizing activity.
In animal cap assay, the authors showed that effects of Chordin was independent of adrenergic signaling, and that ERK activity, which is involved in posteriolization and mesoderm formation, was upregulated. Thus they concluded that adrenergic signaling does not affects neuroectoderm but regulates body axis formation in concert with ERK signaling.
As summarized above, the authors found a novel function, i.e. regulation of A-P axis formation, of adrenergic signaling in early Xenopus embryos in this study, and from this reason this paper is considered to be suitable for the DGD award.

Tong Sun, Bohye Kim and Lou W. Kim
Glycogen Synthase Kinase 3 influences cell motility and chemotaxis by regulating PI3K membrane localization in Dictyostelium
DGD (2013) 55-8, 723-734

Glycogen Synthase 3 (GSK3) has been implicated in the control of cell migration in a variety of organisms. This paper describes detailed analyses of of the role of GSK3 in the regulation of PI3K signaling in Dictyostelium. Combination of biochemical and imaging works provided rich sources of information for resolving contrasting interpretation of GS3 signaling in PI3K signaling in the literature. This work would provide a firm ground for the future investigation on the complex functions of GSK3 signaling in cell migration, and deserves DGD awards.


Editor-in-Chief Prize(Most cited)
Shibata N, Rouhana L, Agata K
Cellular and molecular dissection of pluripotent adult somatic stem cells in planarians
Dev Growth Dfffer (2010) 52-1, 27-41

Total citation:13
Wiley-Blackwell Prize (Most downloaded)
Ramesh S Pillai and Shinichiro Chuma
piRNAs and their involvement in male germline development in mice
Dev Growth Differ (2012) 54-1, 78-92

Total download:1247
Young Investigator Paper Award (DGD 奨励賞)
Namiko Kamiyama, Ryohei Seki, Hitoshi Yokoyama and Koji Tamura
Heterochronically early decline of Hox expression prior to cartilage formation in the avian hindlimb zeugopod
DGD (2012) 54 (6), 619-632

Vertebrate limbs exhibit specie-specific morphological variation. This paper focused on the unique structural feature in chicken hindlimbs where the relative size of the fibula is smaller compared to that of mammals (mouse). This paper extensively compared growth pattern and gene expression of limbs in mammal (mouse), bird (chick), and reptile (gecko). Careful analysis of temporal changes in gene expression has led the authors to suggest that decay of Hoxd11/Hoxd12 expression correlates well with undergrowth of the fibula in chicken. The data is clear and should become a standard reference for the experts of evo-devo studies.

Emiko Yamanishi, Masanori Takahashi, Yumiko Saga and Noriko Osumi
Penetration and differentiation of cephalic neural crest-derived cells in the developing mouse telencephalon
Dev Growth Differ (2012) 54 (9), 785-800.

Cranial pericytes, which wrap cerebral blood vessels to cause vascular constriction and relaxation, originate from the neural crest. The authors genetically marked the cranial pericyte precursors by transgene expression and investigated the process of their entry into the cerebral tissue and their participation in the microvascular system development in relation with endothelial precursors. They showed by using time-focused histological analyses that the pericyte precursors and endothelial precursors form small cell clusters and the clusters invade the cerebral area. They further showed that pericytes assume several different states in the cerebral tissue, including the case where pericyte precursors are distributed in the area to be reached by the blood vessels at later developmental stages. Overall, this study provides new insight into the problems of microvascular development in the cerebrum.

Hiroki Ohgami, Masateru Hiyoshi, Md. Golam Mostafa, Hideo Kubo, Shin-Ichi Abe and Kazufumi Takamune
Xtr, a plural tudor domain-containing protein, is involved in the translational regulation of maternal mRNA during oocyte maturation in Xenopus laevis
Dev Growth Differ (2012) 54 (6), 660-671.

A previous study demonstrated that Xtr (Xenopus tudor repeat) was involved in mitosis at cleavage stages. Because Xtr expression is upregulated during meiosis, it was anticipated that Xtr also played a role in meiosis. The manuscript by Ohgami and colleagues first reported the crucial functions of Xtr in meiosis. In this study, the authors investigated progression of meiosis after micro-injection of the Xtr-specific antibody into maturation-induced Xenopus oocytes, and found that Xtr was necessary for meiotic spindle formation and subsequent chromosomal alignment at meiotic prophase I and II. In addition, among Xtr-interacting mRNA that were involved in karyokinesis, the authors focused on XL-INCEP mRNA and found that translation of XL-INCEP was induced by the function of Xtr via 3’-UTR of XL-INCEP mRNA. Based on the novelty and quality of the data, this manuscript is judged to be suitable for the DGD Award.

Mutsumi Sugio, Chikako Yoshida-Noro, Kaname Ozawa and Shin Tochinai
Stem cells in asexual reproduction of Enchytraeus japonensis (Oligochaeta, Annelid): Proliferation and migration of neoblasts
Dev Growth Differ (2012) 54-4, 439-450

Description of stem cell behavior under normal and injured conditions is important basis for regeneration research. Enchytraeus japonensis (Oligochaeta, Annelid) shows vigorous regenerative capacity after fragmentation. This paper describes behavior of putative stem cell populations (neoblast and N-cell) by BrdU labeling. Information on the behavior of identified stem cells, reported here should be a valuable resource for the future studies on annelid regeneration.


Editor-in-Chief Prize(Most cited)
Yoshihiko Umesono & Kiyokazu Agata
Evolution and regeneration of the planarian central nervous system.
Dev Growth Differ., 51 (3), 185-195, 2009

Total citation:11
Wiley-Blackwell Prize (Most downloaded)
Erina Kuranaga
Caspase signaling in animal development
Dev Growth Differ., 53(2) 137-148

Total download:1085
Young Investigator Paper Award (DGD 奨励賞)
Nariaki Yanagawa, Masahide Sakabe, Hirokazu Sakata, Toshiyuki Yamagishi, Yuji Nakajima
Nodal signal is required for morphogenetic movements of epiblast layer in the pre-streak chick blastoderm.
Dev Growth Differ. 53 (3): 366-377, 2011.

The authors analyzed epiblast cell movement during primitive streak formation, which is a great event in embryogenesis. Using cell labeling in live chicken embryos, they demonstrated that Nodal signal plays a pivotal role in regulating cell movement. The authors also report multiplex analyses of cells’ responses and discuss their observations persuasively, which makes this paper excellent.

Junichi Tasaki, Norito Shibata, Toshihide Sakurai, Kiyokazu Agata, Yoshihiko Umesono
Role of c-Jun N-terminal kinase activation in blastema formation during planarian regeneration
Dev Growth Differ, 53 (3), 389-400, 2011

This paper is excellent because it has elucidated molecular mechanisms of blastema formation from undifferentiated neoblast. It was shown that regeneration signal acccelerates cell cycle by activating JNK activity. The paper clearly shows the relation between JNK activation and blastema formation by looking at cell cycle and blastema markers after treatment with JNK inhibitor.

Noha Dabour, Tetsuya Bando, Taro Nakamura, Katsuyuki Miyawaki, Taro Mito, Hideyo Ohuchi and Sumihare Noji
Cricket body size is altered by systemic RNAi against insulin signaling components and epidermal growth factor receptor
Dev Growth Differ, 53 (7), 857-869

Regulation of growth and life span of the organisms is an important field of research among biologists and medical scientists. The role of insulin signaling in both growth regulation and life span has been extensively studied in model insects such as Drosophila. This paper addressed the control of growth and lifespan of an emerging model organism Cricket by analyzing RNAi knockdown phenotypes of various signaling components by the assays of growth, food uptake and life stage length. The work confirmed the role of Insulin signaling and identified a novel role of EGFR in growth control. This paper is excellent because of its thorough and rigorous analyses and presentation of results in dense and clear Figures in a convincing manner.


Editor-in-Chief Prize(Most cited)
Nagahama, Yoshitaka, Yamashita, Masakane
Regulation of oocyte maturation in fish
DGD 50-S1, S195-219

Total citation:32
Wiley-Blackwell Prize (Most downloaded)
Kazutoshi Takahashi
Direct reprogramming 101
DGD 52-3, 319-333, 2010,
(Special Issue: Mammalian Stem Cells)

Total download: 1073
Young Investigator Paper Award (DGD 奨励賞)
Hideyuki Dekimoto, Toshio Terashima and Yu Katsuyama
Dispersion of the neurons expressing layer specific markers in the reeler brain.
DGD 52 (2) 181-193 (2010)

Nagamoto Kaneko, You Katsuyama, Kazuo Kawamura, and Shigeki Fujiwara
Regenaration of the gut requires retinoic acid in the budding ascidian Polyandrocarpa misakinesis.
DGD 52 (5), 457-468, 2010

Asaka Uejima, Takanori Amano, Naoki Nomura, Miyuki Noro, Taiji Yasue, Toshihiko Shiroishi, Kunimasa Ohta, Hitoshi Yokoyama1 and Koji Tamura
Anterior shift in gene expression precedes anteriormost digit formation in amniote limbs.
DGD 52 (2), 223-234





Other Awards


54th Annual Meeting (ONLINE) Best Oral presentation Awards
084: Makoto Kashima (Aoyama Gakuin University)
“Time-course individual RNA-Seq revealed a transcriptomic landscape of environmental sex determination sex determination in zebrafish”
54th Annual Meeting (ONLINE) Best Poster presentation Awards
139: Soichiro Kato (RIKEN BDR)
“Gating mechanism of blastopore to regulate extracellular fluid dynamics”


52nd Annual Meeting of JSDB Co-sponsored by APDBN Poster Awards
P-053: Seiji Saito (Grad. School of Sci., Nagoya Univ.)
Identification and functional analysis of Gdf11 enhancer that determines the hindlimb position.

P-023: Ryuki Shimada (NIG)
Exploring the murine germ cell masculinization mechanism using scRNA-Seq data

P-070: Hiroki Katsuta (Nagoya Univ. Grad. Sch. Med. Dept. Dev. Cell Biol., Div. Embryology, NIBB)
In vivo calcium signaling induced by mechanosensitive channel Piezo1 during lymphatic valve morphogenesis
リンパ管弁形成過程における機械受容チャネルPiezo1由来のin vivoカルシウムシグナルの役割


Joint Annual Meeting of 70th JSCB and 51st JSDB co-sponsored by Asia-Pacific Developmental Biology Network
=Young Scientist Award for Best Presentation=
[YSA-01] Insulin promotes tumorigenesis by abrogating cell competition
Yuya Sanaki (Kyoto University)
[YSA-03] Genetically-encoded fluorogenic RNA for imaging spatiotemporal mRNA dynamics at
subcellular resolution
Tetsuro Ariyoshi (RIKEN BDR)
=Young Scientist Award =
[YSA-02] Morphological novelty in the vertebrate limb created by the water-to-land
Ingrid Rosenburg Cordeiro (Tokyo Institute of Technology)
[YSA-04] AIP1 and cofilin ensure a resistance to tissue tension and promote directional
cell rearrangement in the Drosophila wing
Keisuke Ikawa (iCeMS, Kyoto univ.)
[YSA-05] Strain-triggered mechanical feedback in self-organizing optic-cup
Satoru Okuda (JST PRESTO, Kyoto Univ.)
[YSA-06] The balance between the mother centrosome associated kinesin KIF-C motor
and Eg5 determines the timing of centrosome separation at mitotic onset
Shoji Hata (MBH, Universitat Heidelberg)
[YSA-07] Tumor progression driven by polyploid giant cells in Drosophila
Bojie Cong (Laboratory of Genetics, Graduate School of Biostudies, Kyoto University)
[YSA-08] Mechanisms of the spindle bipolarity establishment in human acentrosomal cells
Takumi Chinen (Department of Molecular Genetics, National institute of genetics)
[YSA-09] Lineage-specific expansion of homeobox genes and the evolution of spiralian
Yoshiaki Morino (Univ. of Tsukuba)
[YSA-10] Octopamine - Matrix metalloproteinase signaling regulates germline stem
cell proliferation in female Drosophila melanogaster
Yuto Yoshinari (Graduate School of Life and Environmental Sciences, University of Tsukuba)
=Best Poster Presentation Award=
P1-027:Caspase drives Drosophila wing growth independent of apoptosis to ensure the
bilateral symmetry of wing size
Natsuki Shinoda (The University of Tokyo)
P1-095:ERK activation waves mediated by intercellular mechanical signaling during
collective cell migration
Naoya Hino (Kyoto University)
P1-100:Smad signaling and ROS are involved in the “noise-cancelling system” of Wnt/β-
catenin signaling.

Shohei Ogamino (Gunma University)
P1-104:The mechanism about the growth of collagen crystal involved with fin
skeletal development.
Jupei Kuroda (Osaka University)
P1-109:3D Cell behavior in zebrafish somite morphogenesis
Yue Tong (The University of Tokyo)
P1-132:Role of rotational collective cell migration in somite morphogenesis
Harunobu Kametani (The University of Tokyo)
P1-155:Warburg-like metabolism coordinates FGF and Wnt signaling in the
vertebrate embryo
Masayuki Oginuma (Harvard Medical School, Brigham and Women's Hospital)


48th Annual Meeting of JSDB Co-sponsored by APDBN Poster Awards
P031 Yuta Takase (Dept. of Zoology, Grad. Sch. of Sci. Kyoto Univ.)
Blood flow and vascular remodeling: in vivo live-imaging analyses of individual endothelial cells

P138 Tomoya Hasegawa (Tokyo tech)
Chronic inflammation induces the blastema apoptosis during zebrafish fin fold regeneration

P144 Hiroyuki Koga (Univ. Tokyo)
Understanding the mechanisms of dimorphic leaf development of aquatic plants

P-023: Ryuki Shimada (NIG)
Exploring the murine germ cell masculinization mechanism using scRNA-Seq data

P-070: Hiroki Katsuta (Nagoya Univ. Grad. Sch. Med. Dept. Dev. Cell Biol., Div. Embryology, NIBB)
In vivo calcium signaling induced by mechanosensitive channel Piezo1 during lymphatic valve morphogenesis
リンパ管弁形成過程における機械受容チャネルPiezo1由来のin vivoカルシウムシグナルの役割


47th Annual Meeting of JSDB Co-sponsored by APDBN
Poster Awards
Takayoshi Yamamoto(P139B)
(Lab. of Mol. Biol., Dept. of Biol. Scis., Grad. Sch. of Sci., Univ. of Tokyo)
The role of heparan sulfate proteoglycan nanostructures in morphogen gradient formation and signaling reception
Yusuke Mii (P131B)
Spatial localization of noncanonical Wnt proteins during the early Xenopus embryogenesis.
Yoshiyuki Matsubara (P186A)
(Div of Biol Sci, Grad Sch of Sci, Nagoya Univ.)
Heterochrony in initiation of paraxial Gdf11 expression specifies unique hindlimb positioning in tetrapods

Yusuke Okubo (P133A)
(Div. of Cell. and Mol. Toxicol., NIHS)
Analysis of the Delta signaling as the reverse signaling of Notch during mouse development


JSDB-JSCB2012 Young Presenters Award for Excellent Oral Presentation
JWS-A5 Tetsuya Muramoto
Transcriptional pulsing dynamics of genes with different functions

JWS-A6 Shizue Ohsawa
Kobe Univ.
Mitochondrial dysfunction drives non-autonomous tumor progression in Drosophila

JWS-A12 Naohito Takatori
Osaka Univ.
A localized factor polarizes mesendoderm cells and separates mesoderm and endoderm fates in the ascidian embryo.

JWS-B6 Koshi Kunimoto
Osaka Univ.
Coordinated Ciliary Beating Requires Odf2-Mediated Polarization of Basal Bodies via Basal Feet

JWS-B9 Yuko Shimada-Niwa
Univ. of Tsukuba
Neurotransmitter receptors are essential for controlling developmental transition via steroid hormone biosynthesis in Drosophila.

JWS-B10 Rei K. Morikawa
Osaka Biosci. Inst.
Different levels of the TRIM protein Asap confer distinct patterns of axonal connections in Drosophila sensory neurons
JSDB-JSCB2012 Young Presenters Award for Excellent Poster Presentation
P1-049 Daisuke Saito
Primordial germ cells transmigrate from blood stream to gonad in avian: novel behavior revealed by live-imaging analyses

P1-181 Yuki Wakayama
Natl. Cereb. and Cardiovasc. Ctr. Res. Inst.
Cdc42 promotes sprouting angiogenesis through formin-like 3-mediated formation of endothelial filopodia in zebrafish
JSDB-JSCB2012 Young Presenters Award for Poster Presentation
P1-004 Yuji Atsuta
Tubule elongation and cell epithelialization are coordinately regulated by FGFs emanating from adjacent tissues

P1-005 Tokiro Ishikawa
Kyoto Univ.
ATF6 is essential for induction of ER chaperones required for early development

P1-012 Yoshiyuki Matsubara
Nagoya Univ.
Expression timing of Gdf11 and hindlimb position

P1-022 Yusuke Mii
Univ. of Tokyo
Heparan sulfate nanostructures regulate extracellular Wnt distribution and act as a core for Wnt/Dishevelled signalosome formation

P1-029 Yusuke Toyoda
Max Planck Institute A genetic screen and analyses of mitotic cell rounding.

P1-044 Nao Hiramoto-Yamaki
Kyoto Univ.
Cholesterol hops over the compartment boundaries in the plasma membrane an order of magnitude quickly than phospholipids

P1-054 Yoshinori Satoh
Yokohama City Univ.
A Novel Microtubule Binding Protein, MARKAP, plays essential roles for the Golgi-Ribbon Formation by Regulating Golgi-Nucleated Microtubules

P1-063 Chisako Sakuma
Univ. Tokyo
Microtubule interacting protein Dogi is required for neurite branching and elongation in Drosophila olfactory projection neurons

P1-069 Naomi Shinotsuka
Univ. of Tokyo
Live-imaging analysis of SCAT3 transgenic mice revealed the contribution of apoptosis and caspase-activation to the smooth progression of mouse cranial neural tube closure

P1-079 Tetsuhisa Otani
Dynamic Organization of Paracrystalline Actin Bundles by IKKepsilon

P1-090 Masaaki Iwamoto
Biased assembly of the nuclear pore complex determines nuclear differentiation in the ciliate Tetrahymena thermophila

P1-146 Mai Tasaki
Tokyo. Inst.
Tech. Raldh2, an enzyme involved in retinoic acid (RA) biosynthesis, is essential for osteogenesis in the medaka vertebral column.

P1-174 Haruki Ochi
Paralogous enhancers: a crossover point between developmental robustness and stress response

P1-186 Tomoko Yamakawa
Tokyo Univ.of Sci.
Function of a neurogenic gene, pecanex in Notch signaling.


44th annual meeting for
the Japanese society of developmental biologists
(cosponsor: the Asia-Pacific Developmental Biology Network)
Poster Awards
44th annual meeting for
the Japanese society of developmental biologists
(cosponsor: the Asia-Pacific Developmental Biology Network)
Poster Awards
P-1057 Keiichiro Kamura
(RIKEN CDB, Univ. of Tokyo) Dual function of cilia in Kupffer’s Vesicle: generation and sensing of nodal flow
クッペル胞繊毛の2つの働き:nodal flowをつくり、センスする

P-2041 Masafumi Inaba
(FBS) Membrane potential shifts caused by direct contact between pigment cells generate the stripe pattern of zebrafish

P-2078 Chisako Sakuma
(Dept Genetics, Grad Sch Pharm Scis, Univ. Tokyo) Evolutionarily conserved protein Dogi is required for neurite branching and targeting by interacting with microtubule motor regulator Glued in Drosophila olfactory projection neurons
44th annual meeting for
the Japanese society of developmental biologists
(cosponsor: the Asia-Pacific Developmental Biology Network)
Special Award
P-2116 Chizue Hiruta
(Dept. of Nat. His. Sci., Grad. Sch. of Sci., Hokkaido Univ.) Comparative approach to the evolution of ‘abortive meiosis’ found in asexual reproduction of the water flea Daphnia pulex


43rd Annual Meeting for
the Japanese Society of Developmental Biologists
Jointly Sponsored by the Asia-Pacific Developmental Biology Network
43rd Annual Meeting for
the Japanese Society of Developmental Biologists
Jointly Sponsored by the Asia-Pacific Developmental Biology Network
Excellent Presentation Awards
Faculty of Advanced Life Science, Hokkaido University
Discrimination of the functions of Pumilio1 and Pumilio2 in the temporal control of mRNA translation during Xenopus oocyte maturation

P-029 Chu Kit Hang
Department of Biochemistry, Li Ka Shing Faculty of Medicine, The University of Hong Kong
Sox10 mutation affects cochleo-vestibular ganglion gliogenesis

P-030(SW1-04) HATORI RYO
Department of Biological Science and Technology, Tokyo University of Science
Functions of a helix loop helix transcription factor, Extramacrochaetae, in development of left right asymmetry in the Drosophila embryonic hindgut

P-043 Han Yanchao
School of Life Sciences, Tsinghua University
Deficiency of Grhl2 Impairs Otolith and Vestibular Development in Zebrafish Embryos

Gladuate School of Natural Science and Technology, Okayama University
Prepupal period is determined by a common biological timer system in different Drosophila species

P-055 Subramanian Manivannan
National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India
Metabolic Changes in Drosophila Inositol 1,4,5 Trisphosphate Receptor Mutants Confer Resistance to Starvation

P-056 Suganuma Takaya
Division of Biological Science, Graduate School of Science, Nagoya University
An examination on the timing of limb bud induction of Xenopus embryos

P-067 Rai Mamta
Indian Institute of Science, Bangalore, India
Spatio-temporal regulation of indirect flight muscle development and patterning by the transcription factor, erect wing (EWG) in Drosophila.

Korea advanced institute of science and technology
PTEN plays a pivotal role in retinal neurogenesis by supporting Notch signaling

P-081 Kurita Kazuki
Department of Life Systems, Institute of Technology and Sciense, The University of Tokushima
Divergent function of Delta/Notch signaling in formation of body segments in the intermediate-germband cricket Gryllus bimaculatus

P-123 Wang Szu-Chieh
Department of Life Science, Tzu-Chi University
Functional analysis of Aphid Vasa in Drosophila ovary

P-125 Hasegawa Kazuteru
Department of Genetics, School of Life Science, The Graduate University
for Advanced Studies Periodic activation of retinoic acid signaling creates stage-dependent gene expression change in Sertoli cells during mouse spermatogenesis

P-129(HT1-05) Ma Xianjue
Shanghai Key Laboratory for Signaling and Diseases, School of Life Science and Technology, Tongji University
Wallenda regulates JNK-mediated cell death and migration in Drosophila

P-145 Liu Chao
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Prdm14 is required for multiple lineage neuron development in zebrafish

Department of Cell Biology, G-COE, Kobe University Graduate School of Medicine
A non-cell autonomous genetic screen for identifying regulators of cell competition

P-170 Kawanishi Toru
Department of Biological Sciences, Graduate School of Science, University of Tokyo
zic1 and zic4 expression in the somite regulates dorsalization of the medaka trunk

Graduate school of biostudies, Kyoto University
Hunting for Novel Genes that Regulate Planar Cell Polarity: A Mutation of a Cohesin-subunit Gene Affected both PCP and Cell Packing

Department of Genetics, Graduate School of Pharmaceutical Science, University of Tokyo
Apoptosis contributes to normal brain morphogenesis not by restricting cell number but by ensuring the completion of neural tube closure

P-231 Liu Chi-Hsiu
Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University
Molecular Cloning and Characterization of Neuronal Intermediate Filament Protein α-internexin in Chicken Embryos

Developmental Genetics, National Institute of Genetics
Molecular addresses: motifs involved in compartment-specific localization of guidance receptors in Drosophila axons

P-252 Tsang Ka Hing
Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, the University of Hong Kong
Tspyl2 Regulates Hippocampal Long-term Potentiation via NMDA Receptor Subunits Nr2a and Nr2b Expression

P-271 Chan Roy
WL School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong

P-290 Abe Takashi
Department of Morphogenesis, IMCB, University of Tokyo
Sickie, a NEURON NAVIGATOR homolog, is required for the axonal development of Drosophila mushroom body neurons.

P-312 Qiao Yunbo
Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences ,Chinese Academy of Sciences
AP2γ functions as a BMP downstream target to regulate primitive ectoderm fate determination

Department of Biophysics Graduate School of Science, Kyoto University
Studies on the mode of cell division during differentiation of archeocytes(pluripotent stem cells) in sponge, Ephydatia fluviatilis

Division of Germ Cell Biology, National Institute for Basic Biology
Stem cell differentiation is controlled by their progeny in mouse spermatogenesis

P-356 Chien-Yueh Chiang
Developmental Biology, Department of Animal Science, National Chung Hsing University
The reprogramming competence of Xenopus egg/oocyte extracts on NIH/3T3 cells

P-363 Takase Yuta
Graduate School of Biological Science, Nara Institute of Science and Technology
Reciprocal interactions between neural crest cells and blood vessel formation

P-368 Rajaei Flora
Department of Biological Sciences, National University of Singapore
Control of interneuron formation by the DM domain containing transcription factor Dmrt3


Knockdown of ouro genes in tail regression in transgenic Xenopus tadpoles

Analysis of the somite-specific enhancer of the zic genes in medaka: toward understanding of the evolution of the the external morphology in vertebrates.
メダカzic遺伝子の体節特異的エンハンサーの解析; 脊椎動物における外部形態の進化の解明を目指して

Formation of blood vessel network is controlled by the dorsal-ventral patterning of the central nervous system