Seeking a Team Leader RIKEN Center for Integrative Medical Sciences

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Laboratory for Epigenome Inheritance (tentative)
RIKEN Center for Integrative Medical Sciences
Research Field
Laboratory for Epigenome Inheritance aims to elucidate molecular mechanisms underlying epigenetic inheritance in mammals and how these contribute to transmit disease-related genetic traits. In particular, from a viewpoint of disease biology, it will be critically important to explore how environmental stresses given at the parental generation could be imprinted in germ cells and transmitted to the next generation to generate phenotypic changes. Concomitantly, the research will include the area how such epigenetic alterations could be retained beyond epigenetic reprograming that physiologically occur during pre- and/or peri-implantation development. In addition, the successful candidate is expected to contribute to IMS Technology Platform by developing of new technologies to explore chromatin status from low abundant materials.

Job Title and Job Description
Available Positions
One opening for Team Leader position (Principal Investigator position)

Job Description
Team leader will oversee and smoothly manage the research team.
Team leader provide accurate instructions, guidance, and advice to researchers and technical staff, etc. and promote research by the research team at a high level.
Team leader will perform a study to explore the mechanisms underlying epigenetic inheritance in mammals.
Team leader will earn external research funding.
Team Leader will promote research to elucidate the relationship between epigenetic inheritance and disease mechanisms by analyzing the effects of disease and environmental stress on the next generation.
Applicants must have earned a Ph.D. or equivalent degree and have substantial postdoctoral training with a record of excellent research accomplishments suitable to conduct the projects explained above.
Applicants must have research achievements in the relevant field.
Applicants must be those who operate a research team consisting of researchers, etc., and have the ability to lead and promote research.
Applicants are expected to be interested in etiology and pathogenesis of human diseases.
Applicants must be familiar with mammalian reproductive engineering techniques.
Applicants must be familiar with the epigenome of mammalian germ cells, fertilized eggs, and early embryos and have the technology to analyze them with high accuracy.
*The successful applicant will be requested to work full-time in the center.

Work Location
RIKEN Center for Integrative Medical Sciences
1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama-shi, Kanagawa 230-0045 Japan

Salary and Benefits
Terms of contract
1.A fixed-term employee with a single-year contract and can re-contract up to the end of the fiscal year, which marks 7 years from the date of employment by evaluation.
2.RIKEN may adjust the above maximum period of renewability based on a) the employee’s abilities, workload at the time of contract completion, performance and work attitude and b) the continuation of the employee’s center, laboratory, or project and RIKEN’s management situation and budget at the time. In principle, employment contracts will not be renewed for individuals older than 65 years.
3.The employee’s period of fixed-term employment cannot exceed 10 years from the initial date of hire (or 10 years from April 1, 2013 for fixed-term employees already at RIKEN prior to this date).
RIKEN has indefinite-term Team Leader positions, which are subject to the mandatory retirement age of 60. There is a subsequent re-employment program allowing hiring until age of 65. Any scientists, including fixed-term Team Leaders of RIKEN, are eligible to apply to open calls for indefinite-term positions.

Salary, Holidays, Other provisions
There will be a trial period of employment (in principle, 2 months).
Salary will be commensurate with qualifications and experience. Commuting and housing allowances will be provided. Social security insurance will be applied. Mandatory membership in the RIKEN Mutual Benefit Society (RIKEN Kyosaikai) is required.
Work hours: 9:00 to 17:20 (lunch break 12:00 to 12:50). However, the employee may change starting and ending times at their own discretion if it does not interfere with work performance.

Days off include public holidays, New Year's holidays (Dec. 29 - Jan 3), and RIKEN Foundation Day.
Paid leave includes annual paid leave (up to 20 days per year depending on the month of employment), special paid leave (childcare, family nursing care, etc.), and work-life balance holidays (up to 7 days per year depending on the month of employment).
There are also additional leave systems such as maternity leave, childcare leave, and family nursing care leave.

RIKEN has introduced telework as a temporary and special measure to prevent the spread of COVID-19. You may be asked to work from home according to the instructions of the institute.

Smoking is prohibited on the premises except in smoking areas.
These and other provisions are in accordance with RIKEN regulations.

RIKEN is actively undertaking initiatives to promote gender equality and diversity, and moving forward with the establishment of a diverse and vibrant research environment. If multiple candidates are found to have the same aptitude following a fair assessment, active efforts will be made to recruit female candidates.

Also, the employee is eligible for an exemption from repayment for category 1 scholarship loans provided by the Japan Student Services Organization before fiscal year 2003 and is eligible to apply for MEXT Grants-in-Aid for Scientific Research (Kakenhi).

Documents to Submit
Prepare the documents below as PDF files and send them to IMS-recruit [at] riken.jp

*Write “Application Documents; [IMS701-2101] Laboratory for Epigenome Inheritance Team Leader” in the subject line.

1.CV (WORD 55.4KB)The webpage will open in a new tab. or CV (EXCEL 57.6KB)The webpage will open in a new tab. with photograph and email address.
*In the top right-hand corner of the CV, please indicate open-call IMS701-2101.
*Using the RIKEN format above is appreciated.
2.List of publications (primary publications, reviews, and books), presentations, etc. in the past ten years.
3.Major publications. [Up to five. Indicate the papers that will be submitted on the list of publications (#2).]
4.Future research plans and research philosophy/vision (Up to five double-spaced A4-size pages) including;
Abstract of your research plans and vision.
Specific description of your near-term (5-year) research plans - their significance, originality, novelty, and expected impact. Include a brief description of previous research and achievements that form the basis of your plans.
List of competitive external funding awarded currently and in the last 5 years as well as currently-submitted / under-review proposals (e.g. Grants-in-Aid for Scientific Research [KAKENHI]; indicate
whether you are the primary investigator or a collaborator)
5.One letter of recommendation from your current supervisor, as well as letters of recommendation from two researchers not affiliated with RIKEN.
*Recommendation letter should be addressed to "Dr. Hiroshi Matsumoto, President of RIKEN" and include the recommender's name, affiliation, position and email address.
*If it is difficult to obtain a recommendation letter from your current supervisor, a recommendation from a third party will be accepted.
*The person has to send the recommendation directly by email to IMS-recruit [at] riken.jp
*The signature (or seal) of the person providing the recommendation is required.
Please put "Recommendation letter for (name of applicant)" in the subject line.
6.Certificate of graduation or copy of diploma for the highest degree obtained (photocopy acceptable).
7.Consent form for handling personal information based on GDPR
If you are a resident of the European Economic Area (EEA), you are required to submit the document, "Consent form for handling personal information based on GDPR (PDF 97KB)The webpage will open in a new tab." with your signature.
*You will find detailed information about General Data Protection Regulation (GDPR) on the following website:
Data protection | European CommissionThe webpage will open in a new tab.

Note: Application documents will not be returned.

By noon on January 24 (Mon.), 2022 (Japan Standard Time)

*All required documents must be submitted by the deadline.

Handling of Personal Data
All private data sent to RIKEN in the application for employment is handled in strict confidentiality, and such data is not utilized for any other purpose or disclosed to any third party.

Selection Process
Applicants who pass the initial document screening will be invited for an interview.
During the interview, you will be asked to give a presentation on your work plan and future aspirations.

Start of Employment
June 1, 2022, or the earliest date possible (negotiable)

Contact Information
Any questions about this position should be sent to the appropriate email address below.

For application documents and general questions
Recruiting Staff for RIKEN Center for Integrative Medical Sciences
Administrative Division, RIKEN Yokohama Branch
Email: IMS-recruit [at] riken.jp

For research-related questions
Integrative Medical Sciences and Sustainable Resource Sciences Promotion Office
Email: ims-planning [at] ml.riken.jp

Posttdoctral position in Developmental Biology Center the University of Minnesota

Several postdoctoral positions are available in Drosophila labs (Thomas Neufeld, Hiroshi Nakato, and Michael O'Connor) at the Developmental Biology Center, the University of Minnesota.

The Neufeld lab is interested in mechanisms of autophagy regulation by nutrient-dependent signaling in Drosophila. Current projects focus on how autophagosome maturation, acidification and fusion are regulated by the mTOR pathway, and how nutrient release from the larval fat body supports development of peripheral tissues.

The Nakato lab studies the molecular mechanisms of the regeneration termination using the Drosophila intestinal stem cell model. The failure of proper termination of tissue regeneration results in the emergence of unwanted cells, leading to a high risk of cancer. However, it is poorly understood how a damaged tissue senses when to terminate the regeneration process and inactivates stem cell mitotic activity. The project focuses on the roles the microRNA-mediated network in stem cell control during regeneration termination.

The O’Connor lab is interested in understanding the physiological mechanisms by which tissues coordinate their growth and remodeling during development. One project seeks to identify the upstream signals and downstream effectors in the neuroendocrine pathway that controls initiation of metamorphosis. A second area of study is to elucidate the network architecture of Activin signaling that controls Drosophila body size, tissue scaling and metabolism in response to various environmental inputs including nutrition, stress, temperature, pathogens, and population density. Previous experience with either molecular genetics, bioinformatics, metabolic measurements, optical/EM imaging, and/or biochemical methods is preferred.

The Developmental Biology Center (https://cbs.umn.edu/academics/departments/gcd/dbc) provides a rich environment for interaction with a large group of investigators using diverse approaches and systems to study all aspects of development. Postdoctoral trainees at the University of Minnesota are offered a supportive mentored environment with opportunities for professional development (https://pda.umn.edu). DBC is centered in the Twin Cities of Minneapolis and Saint Paul, which consistently ranks as one of the top places to live in the U.S. and is a hub for biotech and biopharmaceutical companies.

All positions are immediately available (with flexible start date). Interested individuals should email Tom Neufeld (neufe003@umn.edu), Hiroshi Nakato (nakat003@umn.edu), or Mike O'Connor (moconnor@umn.edu).

Seeking Team Leaders RIKEN BDR

Seeking Team Leaders
RIKEN Center for Biosystems Dynamics Research

【Open positions】
Team Leader: A few position

A holder of Ph.D. or equivalent degree.

【Work location】
RIKEN Center for Biosystems Dynamics Research (Kobe Campus-East-West)
2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan

【Research field】
The RIKEN Center for Biosystems Dynamics Research (BDR) aims to understand the general principles of organismal temporal dynamics throughout the lifespan from birth to death, including aging. Our interdisciplinary approaches include imaging, multi-omics, theory, molecular biology, stem cell biology, organoids, and diverse animal models.

We are now seeking to recruit Team Leaders who conduct challenging and innovative research to pioneer new fields of life cycle science. How organisms including humans control the transitions of life stages, and how they achieve long-term control across distinct life stages, are our keen interests. Topics include metabolic, epigenetic, and morphogenetic transitions in the life cycle, multi-organ interactions, stem cell-based tissue maintenance, transgenerational interactions (e.g. mother-to-fetal communication), aging, and any other topics that will potentially lead to conceptual advances in life cycle science. We encourage proposals using unprecedented interdisciplinary approaches, such as combinations of reconstructing organs, comparing diverse animal models and primates including human subjects, linking events at multiple scales from molecules and cells to tissues and organs, and taking advantage of any other cutting-edge technologies.

BDR provides early-career Team Leaders with an excellent environment for their independent research, including internationally competitive start-up packages and annual research funds as well as mentoring by experienced senior PIs. The Team Leader will have access to cutting-edge facilities including for various animal models, mouse genome engineering, multi-scale imaging and omics, and structural biology, and have opportunities for active collaborations with medical institutions, industry, and affiliated graduate schools. For more information, please visit the BDR website(https://www.bdr.riken.jp/en/index.html).

We welcome applications from candidates of any gender or nationality, and encourage applications from those who will broaden RIKEN's diversity. The working language for all discussions open to BDR members is English.

Applications must arrive no later than noon, February 28, 2022 (Japan Standard Time)

【Start of employment】
Negotiable (After October 1, 2022)

For more information and required application documents, please visit the application website:

Seeking a Research Scientist RIKEN BDR

Seeking a Research Scientist
Laboratory for Lung Development and Regeneration
RIKEN Center for Biosystems Dynamics Research
(Team Leader: Mitsuru Morimoto)

【Open positions】
Research Scientist: 1 position

Doctoral degree (or equivalent research ability and background) in the relevant research field.

【Initial work location】
RIKEN Kobe Campus (2-2-3, Minatojima-minamimachi, Chuo-ku, Hyogo 650-0047)
The successful candidate will be based at the RIKEN BDR-CuSTOM Joint lab at the Cincinnati Children’s Hospital Medical Center (USA) on a long-term business trip for the duration of the joint research (until March 2023). Following the completion of the joint research, they will work at RIKEN (Japan). Travel and accommodation expenses will be paid in accordance with RIKEN regulations.
Cincinnati Children’s Hospital Medical Center
3333 Burnet Avenue, R3.563 | MLC 7007 | Cincinnati, OH 45229-3039

【Research field and overview】
・Lab for lung development and regeneration
・RIKEN BDR-CuSTOM joint-lab
The lab conducts researches on the mechanisms of cell proliferation and differentiation, tissue morphology, and tissue stem cells during development and regeneration of the respiratory organs. We apply these knowledge to reconstitute mouse and human respiratory organs from ES/iPS cells. The RIKEN BDR-CuSTOM Joint-Lab, established in Cincinnati in 2019, is designed to promote international collaboration between the two centers. We are developing the next generation of organoid culture technology by combining the expertise of both centers.

【Job description】
The RIKEN Center for Biosystems Dynamics Research(BDR) is collaborating with the Center for Stem Cell & Organoid Medicine (CuSTOM) at Cincinnati Children's Hospital in the USA on research regarding the production of respiratory organoids. The selected researcher will be assigned to the joint laboratory in Cincinnati, where he or she will work on the induction of organoids of respiratory and peripheral organs from human ES/iPS cells. The candidate should have broad knowledge in endodermal development including respiratory organs, and a strong experience in quantitative analyses of organogenesis and tissue culture skills for inducing organoids from human pluripotent cells. The researcher will be expected to maintain friendly relationships with the staff of RIKEN and CuSTOM in order to facilitate the joint projects conducted by the two centers. The successful candidate is also expected to conduct research and development on topics specified above and to contribute to the management of the laboratory.

For applicant registration:
Noon, October 15, 2021 (Japan time).

For revising or uploading application documents and letters of recommendation:
Noon, October 21, 2021 (Japan time).

【Start of employment】
RIKEN expects that the successful applicant will be able to take up this position at the earliest opportunity after April 1, 2022.

For more information and required application documents, please visit the application website:

Seeking a Head of a New Laboratory (indefinite-term employment position) RIKEN BDR

Seeking a Head of a New Laboratory (indefinite-term employment position)
RIKEN Center for Biosystems Dynamics Research

【Open positions】
Laboratory Head: 1 position (full professor level)

Applicants must have an outstanding research record and the ability to lead the above research field internationally. We welcome applicants of all nationalities.

【Work location】
RIKEN Kobe Campus (2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047)

【Research field and overview】
RIKEN's research is based on synthesis and interdisciplinarity, and with free thinking as its basic philosophy, RIKEN promotes research that goes beyond the boundaries of conventional research fields, while at the same time responding to the needs of society from a strategic perspective.

RIKEN invites applications for the position of Laboratory Head (indefinite-term employment position) to serve in a leadership position in the following research area. The successful candidate will be responsible for directing research projects from a mid-to-long-term perspective.

Field: Adult dynamic homeostasis
Basic research related to adult dynamic homeostasis. Topics of keen interest include studies that lead to ground breaking findings on the life-long regulation of the maintenance, aging, deterioration, and inheritance of biosystems throughout the life cycle from the birth to death or to the next generations. We encourage proposals that include focuses on undifferentiated or multipotent stem cells in adults, or any pioneering researches that aim to contribute to the understanding of biological processes in the adult stages of the life cycle. Successful proposals are expected to promote and take advantage of the interdisciplinary approaches within the RIKEN Center for Biosystems Dynamics Research (BDR) as well as all of RIKEN.

The RIKEN BDR aims to understand the general principles of organismal temporal dynamics throughout the lifespan from birth to death, including aging. Our interdisciplinary approaches include imaging, multi-omics, theory, molecular biology, structural biology, stem cell biology, organoids, and diverse animal models. BDR provides Laboratory heads with an excellent environment for their independent research, including internationally competitive start-up packages and annual research funds. Laboratory heads will have access to cutting-edge facilities including various animal models, mouse genome engineering, omics, and multi-scale imaging including light microscopy and cryoEM, and to opportunities for active collaborations with medical institutions, industry, and affiliated graduate schools. For more information, please visit the BDR website(https://www.bdr.riken.jp/en/index.html).
This call seeks a scientist from outside RIKEN who will lead the field of adult dynamic homeostasis internationally and play a central role in fulfilling the BDR’s missions, while being committed to tasks as a laboratory head at RIKEN.

The application must arrive no later than noon, December 10, 2021 (Japan Standard Time)

【Start of employment】
October 1, 2022 or earliest possible date after this date.

For more information and required application documents, please visit the application website:

Posttdoctral position in Keil University (Dr. Alexander Klimovich group)

I am looking for a new member of the team - a motivated and independent postdoc experienced in bioinformatics who could spearhead the project "Functional diversity of taxonomically restricted genes in Hydra" in my group.

The project is dedicated to deciphering the role of taxonomically restricted genes (TRGs, a.k.a. orphan genes) in development and differentiation of cell types, particularly neurons. The primary goal of the project is to gain insights into the structural and functional diversity of proteins encoded by TRGs in the genome of the freshwater polyp Hydra. The main objectives will be: i) consolidation of existing Hydra genomic data (Chromium 10X, PacBio, Nanopore); ii) detailed annotation of the Hydra genome - its repertoire of conserved and, especially, non-conserved, orphan genes; iii) integration of data on expression of these genes in cell types and during ontogenesis (including single-cell RNA-Seq). I need an experienced bioinformatician to accomplish these tasks. Nevertheless, lab experience is also very welcome, and there is definitely a use for it.

I offer a postdoc contract for 2 years. In addition, resources for consumables and a lab technician are also secured. The application deadline is 1st August 2021, anticipated start of the contract 1st September 2021. Given the current constraints, it is possible to start working on the project remotely, and join the lab in Kiel only in the second year of the contract.

Potential candidates are welcome to contact me directly.
Dr. Alexander Klimovich
Christian-Albrechts-University Kiel
Zoological Institute
Am Botanischen Garten 1-9
24118 Kiel, Germany
Phone: 49-431-8804178; Fax: 49-431-8804747
Email: aklimovich@zoologie.uni-kiel.de
Web: https://www.alexander-klimovich.com

Postdoctoral Position in Oklahoma Medical Research Foundation

Staff Scientist/ Postdoctoral Fellow

The Srinivasan Lab at Oklahoma Medical Research Foundation (OMRF) studies lymphedema, heart valve disease and obesity. The lab uses state of the art biochemical, cell biological and transgenic technologies to dissect the roles of transcription factors and signaling molecules. Please check our latest publications: Cha et al (2016) Genes Dev. (cover image) June 16; 30: 1-16; Cha et al (2018) Cell Reports. (cover image) October 16; 25(3):571-584; Mahamud et al (2019) Development. November 5;146(21):dev184218 and Geng et al (2020) JCI Insight. (cover image) July 23;5(14):e137652.

We are recruiting highly motivated researchers with experience in Cell biology, Molecular Biology, Biochemistry or Immunology.

Required Qualifications
Ph.D., M.D., or Ph.D./M.D.,

Fresh graduates will be considered for postdoctoral fellowships, and more experienced researchers will be considered for the position of Staff Scientist. Salary of postdoctoral fellows is according to the stipulation of NIH. Salary of the Staff Scientist will be commensurate with experience. Preference will be given to candidates with at least one first-author publication in respected journals. Please send CV, list of 3 references, reprints of publications and a brief summary of interests and career goals to Sathish-srinivasan@omrf.org.

OMRF is an independent, not-for-profit, biomedical research institute in Oklahoma City, USA. OMRF has been selected as one of the best research institutions for post-docs from 2011 to 2013 in the USA by The Scientist journal. Oklahoma City metropolitan area offers affordable housing, low cost of living, great public schools and numerous recreational activities. Additional information about OMRF can be found at http://omrf.org.

Postdoctoral Position in Evolutionary Developmental Biology of Fish Rutgers the State University o

The Nakamura lab in Department of Genetics at Rutgers university has a postdoctoral position available (http://nakamuralab.com/). The long-term goal of Nakamura lab is to identify the genetic mechanisms underlying fish diversity and their contribution to the fish-to-tetrapod transition. We are particularly interested in how fish fin skeletons diversified and evolved into tetrapod limbs. To this end, we bridge functional genomics, genetics, and embryology using model and non-model organisms, including zebrafish, skates, and sharks. More information about ongoing research projects can be found on the lab website.

Candidates should have strong research records in any of the following areas: developmental biology, evolutionary biology, genomics, or other relevant fields. Our lab is a highly interdisciplinary environment, therefore, scientific curiosity and strong communication skills are necessary. Experience in zebrafish embryology, high-throughput sequencing, or bioinformatics data analysis is preferred, but not required.

Rutgers University is located in New Brunswick, NJ, which is only 45 minutes away from NYC by train. Many competitive research universities and institutes are in the Northeast area, offering remarkable opportunities for collaboration and research conferences. The Nakamura lab regularly visits the American Museum of Natural History (https://www.amnh.org/) and the Marine Biological laboratory (https://www.mbl.edu/) for the purpose of analyzing unique specimens and educating students.

Candidates should send a curriculum vitae, brief statement of current research, and contact for 3 references to nakamura@dls.rutgers.edu (Tetsuya Nakamura).